Lipolysis of hepatic triacylglycerol stores
نویسندگان
چکیده
منابع مشابه
Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone.
Hepatic VLDL (very-low-density lipoprotein) assembly is a complex process that is largely regulated by the provision of lipid for apolipoprotein B assembly. Intracellular stored TAG (triacylglycerol) undergoes an initial lipolysis followed by re-esterification of the lipolytic products to form TAG prior to their incorporation into a VLDL particle. TGH (TAG hydrolase) is a lipase that hydrolyses...
متن کاملControl of hepatic triacylglycerol metabolism.
Avigan, J., Williams, C. D. & Blass, J. P. (1970) Biochim. Biophys. Acta 218,381-384 Betteridge, D. J., Higgins, M. J. P. & Galton, D. J. (1975) Br. Med. J . 4,5W502 Brown, M. S. & Goldstein, J. L. (1976) Science 191,150-154 Brown, M. S., Faust, J. R. & Goldstein (1975) J. Clin. Invest. 55, 783-793 Christophe, J. & Popjhk, G. (1961) J. Lipid Res. 2,244-257 Danielsson, H. (1972) Steroids 20,63-7...
متن کاملLysosomal triacylglycerol lipase and lipolysis in isolated rat hepatocytes.
Triacylglycerol lipase activity in homogenates from isolated rat hepatocytes was almost completely confined to the acidic region of the pH curve. Maximal activity was found at pH 4.4; a small shoulder was observed at pH 6.6. Very little lipolytic activity and no pH optimum could be detected over the pH range 7.4 to 9.6. The subcellular distribution patterns of lipolytic activity at pH 4.4 and 6...
متن کاملHepatic triacylglycerol accumulation and insulin resistance.
The association of hepatic steatosis with hepatic insulin resistance and type 2 diabetes has prompted investigators to elucidate the underlying mechanism. In this review we focus on pathways of lipid metabolism, and we review recent data, primarily from mouse models, that link lipid intermediates with insulin resistance. Most of the studies that implicate acyl-CoA, lysophosphatidic acid, phosph...
متن کاملRegulation of hepatic triacylglycerol synthesis and lipoprotein metabolism by glucocorticoids.
The excessive synthesis and storage of triacylglycerol (triglyceride) has a number of clinical implications. It is obviously the main symptom of obesity where excess lipid is stored in adipose tissue. Abnormal accumulations of triacylglycerols can also be manifested as a fatty liver, e.g. as a'result of the ingestion or inhalation of toxic compounds and damage to the liver. These conditions are...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1982
ISSN: 0014-5793
DOI: 10.1016/0014-5793(82)80884-3